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RAS BiologyИзвестия Российской академии наук. Серия биологическая Biology Bulletin

  • ISSN (Print) 1026-3470
  • ISSN (Online) 3034-5367

Bioinformatic and behavioral analysis of pannexin 1 involvement in cutaneous perception in mice

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PII
S30345367S1026347025050086-1
DOI
10.7868/S3034536725050086
Publication type
Article
Status
Published
Authors
O.O. Kiryukhina
  • Affiliation: A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences
O.S. Tarasova
  • Affiliation:
    A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences
    Research Institute of Physical Chemistry and Biology named after A.N. Belozersky
Volume/ Edition
Volume / Issue number 5
Pages
572-579
Abstract
To reveal new functions of pannexin 1 in the mouse nervous system, cell types with the most pronounced expression of the gene encoding this protein were identified by bioinformatic analysis. It turned out that sensory neurons PSNP3 and PSNP6 of the dorsal root ganglia have the highest expression levels of Panx1, as well as high expression of purinoreceptor p2rx3, and other genes associated with the perception of pain and skin itch. The scratch reflex induced by compound 48/80 was suppressed in Panx1 knockout mice compared to wild-type mice, confirming the involvement of Panx1 in the purinergic regulation of sensory nerve fibers responsible for itch perception.
Keywords
паннексин 1 кожная чувствительность прурицепция ноцицепция ганглии дорсальных корешков
Date of publication
03.03.2025
Year of publication
2025
Number of purchasers
0
Views
61

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